Abstracts
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L. Hancock1,2, T. Ahmad1, B. F. Warren3, N. J. Mortensen2, D. P. Jewell1.Departments of 1Gastroenterology, 2Colorectal Surgery, 3Histopathology, University of Oxford, Radcliffe Infirmary, Oxford OX2 6QX, UK
Background: Clinical, serological, and molecular data support the existence of discrete subsets of Crohn’s disease (CD) defined by location of disease. Little is known about the epidemiology and natural history of isolated CD of the colon (Montreal Classification L2) because most studies have not accurately distinguished L2 from L3 disease (ileo-caecal).
Aims: (1) To describe the clinical features and natural history of isolated colonic CD in a rigorously characterised patient cohort. (2) To confirm the association with HLA-DRB1*0103, reported in smaller cohorts, and to investigate its role in predicting disease course and need for surgery.
Methods: Patients with L2 disease were identified from a database of 1318 CD patients. Only patients with a normal small bowel enema
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