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Guidelines for resection of colorectal cancer liver metastases

¹ Clinical and Surgical Sciences (Surgery), University of Edinburgh, Royal Infirmary, Edinburgh, UK
² Royal North Hampshire Hospital, Basingstoke, UK
³ University Hospital Aintree, Liverpool, UK
⁴ Liver Surgery Unit, Queen Elizabeth Hospital, Birmingham, UK
⁵ Christie Hospital NHS Trust, Withington, Manchester, UK
⁶ University College Hospital, London, UK
⁷ University of Southampton, Southampton General Hospital, Southampton, UK
⁸ Clinical and Surgical Sciences (Surgery), University of Edinburgh, Royal Infirmary, Edinburgh, UK

Correspondence to:
Correspondence to:
Professor O J Garden
Clinical and Surgical Sciences (Surgery), University of Edinburgh, Royal Infirmary, 51 Little France Crescent, Edinburgh EH16 4SA, UK; OJGarden@ed.ac.uk

Revised version received 31 March 2006
Accepted for publication 31 March 2006

Abbreviations: MDT, multidisciplinary meeting; CT, computed tomography; CEA, carcinoembryonic antigen; MRI, magnetic resonance imaging; FDG, F-18 fluorodeoxyglucose; PET, positron emission tomography; CLOCC trial, chemotherapy + local ablation versus chemotherapy trial

Keywords: hepatic resection; liver metastases; colorectal cancer; guidelines; chemotherapy

The first 150 words of the full text of this article appear below.

	1.0 INTRODUCTION

 
There has been increasing recognition of the potential benefits of liver resection for colorectal metastases in the UK although this treatment has been established more widely in other Western countries. There are no randomised studies assessing outcome following resection compared with no treatment or other therapeutic modalities in patients with known resectable liver metastases as it is generally considered unethical not to offer surgery for resectable disease. There has been increased interest in more aggressive chemotherapy regimens that have been reported to not only control metastatic disease but also to render some advanced liver metastases resectable.^1–4 Furthermore, other new modalities have become available that allow safe ablation of liver metastases without the need for surgical intervention. There is therefore a need to produce clear guidelines on the appropriate management of patients with colorectal cancer who have been shown to have hepatic metastases.

These guidelines are intended to address a number . . . [Full text of this article]