Digest
| The first 150 words of the full text of this article appear below. |
Improving the barrier to gastro-oesophageal reflux using endoscopic suturing is undoubtedly attractive, but placebo effects are likely to be large. This study, the first randomised sham-controlled trial of this treatment, is therefore welcomed. Patients who were reliant on proton pump inhibitors (PPIs) were randomised to three groups; active treatment, sham treatment or observation only. Sixty patients were enrolled and partial or complete 3-month data were available for 57 of them. After 3 months, 65% of patients in the active group had reduced use of PPIs compared with 25% in the sham group and none in the observation-only group. The benefit persisted, although with diminishing magnitude at 6 and 12 months. Symptoms and quality of life were also improved. Surprisingly, both active and sham groups showed a similar fall in acid exposure, raising the question of exactly how endoscopic gastroplication works. The authors found a large percentage of loose sutures during
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
Relevant Articles
- Selective effects of nutrients on gut sensitivity and reflexes
- M P Caldarella, F Azpiroz, and J-R Malagelada
Gut 2007 56: 37-42.[Abstract] [Full Text] [PDF]
- Treatment of experimental murine pancreatic peritoneal carcinomatosis with fibroblasts genetically modified to express IL12: a role for peritoneal innate immunity
- J M Péron, C Bureau, P Gourdy, H Lulka, A Souque, B Calippe, J Selves, T Al Saati, J Bernad, P Cordelier, B Couderc, L Pradayrol, B Pipy, L Buscail, and J P Vinel
Gut 2007 56: 107-114.[Abstract] [Full Text] [PDF]
- GITR modulates innate and adaptive mucosal immunity during the development of experimental colitis in mice
- L Santucci, M Agostini, S Bruscoli, A Mencarelli, S Ronchetti, E Ayroldi, A Morelli, M Baldoni, and C Riccardi
Gut 2007 56: 52-60.[Abstract] [Full Text] [PDF]
-
Tumour necrosis factor
blockade induces an anti-inflammatory growth hormone signalling pathway in experimental colitis
- X Han, N Benight, B Osuntokun, K Loesch, S J Frank, and L A Denson
Gut 2007 56: 73-81.[Abstract] [Full Text] [PDF]
- Endoscopic gastroplication for the treatment of gastro-oesophageal reflux disease: a randomised, sham-controlled trial
- M P Schwartz, H Wellink, H G Gooszen, J M Conchillo, M Samsom, and A J P M Smout
Gut 2007 56: 20-28.[Abstract] [Full Text] [PDF]
- Cholestasis protects the liver from ischaemic injury and post-ischaemic inflammation in the mouse
- P Georgiev, A A Navarini, J J Eloranta, K S Lang, G A Kullak-Ublick, A Nocito, F Dahm, W Jochum, R Graf, and P-A Clavien
Gut 2007 56: 121-128.[Abstract] [Full Text] [PDF]
Services
- Email this link to a friend
- Similar articles in this journal
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
