COMMENTARY
2
ligand and IBS
2
ligand: a new, smart pill for visceral pain in patients with hypersensitive irritable bowel syndrome?
Correspondence to:
Correspondence to:
Dr Michael Camilleri
Mayo Clinic, Charlton 8-110, 200 First St SW, Rochester, MN 55905, USA; camilleri.michael@mayo.edu
| The first 150 words of the full text of this article appear below. |
The heteromultimeric voltage-sensitive calcium (Ca2+) channel is involved in the function of excitable tissues including sensory nerves. It comprises a primary 1 subunit and auxiliary 2, ß and 
subunits, and the associated 2 ligand-binding site (see fig 1
). The 1 subunit forms the ion-conducting pore and serves as voltage sensor. The 2 subunit consists of the highly N-glycosylated extracellular 2 protein attached to the membrane-spanning protein that binds divalent metal cations and interacts directly with the 1 subunit. The ß subunit is an intracellular protein that mediates modulation of Ca2+ channel function by intracellular kinases. The subunit is a glycoprotein with four transmembrane segments.1
Figure 1 Three dimensional reconstruction of the L-type calcium channel showing | |||||||||
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