Commentaries
Obesity and adenocarcinoma
Obesity and the rising incidence of oesophageal and gastric adenocarcinoma: what is the link?
Correspondence to:
Douglas A Corley, Division of Research, 2000 Broadway, Oakland, California 94612, USA; Douglas.corley@kp.org
While data support an association between BMI and oesophageal adenocarcinoma, it is not known why the cancer incidence differs so markedly by gender and ethnicity
| The first 150 words of the full text of this article appear below. |
The incidence of oesophageal adenocarcinoma has increased over 500% in some countries during the last three decades, but the reasons for this rise are unclear.1 The most intractable problem to date has been explaining why the rates for oesophageal adenocarcinoma vary substantially by race (more common in Caucasians), gender (more common in men), and geography.1–6 The increasing prevalence of obesity in society may provide a partial explanation for the increases in incidence. The article by Merry et al. in this issue of Gut describes a well-designed cohort study which evaluates whether measures of body size, such as height and the body mass index (BMI), are associated with the subsequent risk of oesophageal and gastric cardia adenocarcinomas (see page 1503).7 Its strengths include its cohort design, high-quality data, the ability to evaluate BMI early in adult life (when carcinogenic processes such as Barrett’s oesophagus may begin)
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