Gut tutorials

Helicobacter pylori and antibiotic resistance

Francis Megraud

Laboratoire de Bacteriologie, CHU Pellegrin, Bordeaux, France

Correspondence to:
Dr F Megraud, Laboratoire de Bacteriologie, CHU Pellegrin, 33076 Bordeaux cedex, France; francis.megraud@chu-bordeaux.fr

The first 150 words of the full text of this article appear below.

This is an introduction to the Gut tutorial "Helicobacter pylori and antibiotic resistance" hosted on BMJ Learning—the best available learning website for medical professionals from the BMJ Group.

H pylori is a Gram-negative flagellated spiral bacteria. Infection with H pylori is mainly acquired in childhood. About 15% of infected people will develop a peptic ulcer and 1% will develop gastric cancer during their lifetime. Resistance to antibiotics is important as it leads to treatment failure. The prevalence of H pylori resistance to clarithromycin is <5% for adults in northern Europe, but as high as 20% in southern Europe. Resistance to clarithromycin is caused by previous consumption of macrolides. Resistance is higher in children because prescriptions of these drugs, particularly for children, have increased during the past decade, mainly for respiratory tract infections. The prevalence of H pylori resistance to metronidazole varies from 20–40% in Europe and the USA to . . . [Full text of this article]

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