Digest
| The first 150 words of the full text of this article appear below. |
There is great interest in "nutriceuticals" for disease prevention and treatment, but many commercially available products are sold without rigorous scientific validation. One such product is zinc carnosine (ZnC), which is sold as a dietary supplement with "added value for gastric health". The authors assess the effect of ZnC on various models of gut injury and repair and in a clinical trial. In vitro studies showed that ZnC caused a threefold increase in cell migration and proliferation, which are surrogate markers of wound repair. ZnC reduced indomethacin-induced gastric injury by 75% in a rat model (see fig
) and reduced small intestinal injury by 50% in a similar mouse model. In the clinical study, healthy volunteers undertook a randomised, crossover trial comparing changes in gut permeability before and after 5 days of indomethacin with ZnC or placebo coadministration. Indomethacin caused a threefold increase in gut permeability, while coadministration of ZnC
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