COMMENTARY

Oesophageal ulcerations

Treatment of oesophageal ulcerations using endoscopic transplantation of tissue-engineered autologous oral mucosal epithelial cell sheets in a canine model

George P Yang¹, Roy M Soetikno²

¹ Departments of Surgery, Stanford University School of Medicine, Stanford, California, USA; Veterans Affairs Healthcare System, Palo Alto, California, USA
² Departments of Medicine, Stanford University School of Medicine, Stanford, California, USA

Correspondence to:
Correspondence to:
Dr Roy M Soetikno
Palo Alto Medical Clinic, Veterans Affairs Palo Alto Healthcare System, Palo Alto, California 94304, USA; soetikno@earthlink.net

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Endoscopic transplantation in oesophageal ulceration

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The first 150 words of the full text of this article appear below.

The late transplantation pioneer, Norman Shumway, MD, was fond of saying, "The future of transplantation is xenotransplantation. And, it always will be." Tissue engineering, the in vitro creation of functional replacement tissues, has been proposed as a way to replace lost or damaged tissues due to acute or chronic disease for nearly 20 years.¹ Despite the tremendous interest, there are a few tissue-engineered constructs that have gained considerable acceptance in clinical use, although progress is being made. Ohki et al², demonstrate recent progress of the potential application of tissue engineering in endoscopy.

The complexity of organs and the lack of knowledge of how these organs are patterned in their development have made tissue engineering of solid organs like the liver difficult.³ In the case of the liver, the construct must have two separate vascular inflows, a single vascular outflow and a separate biliary drainage system. This also . . . [Full text of this article]

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