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Does quality of life influence development of dyspepsia? Ford et al attempted to answer this important question by conducting a 10-year, longitudinal, follow-up study of subjects who were screened for Helicobacter pylori infection. Using a validated postal dyspepsia questionnaire, they contacted 8407 individuals. Of these, 3912 (46.5%) provided symptom data at baseline and at 10-year follow up. Two thirds of these individuals (2550) were asymptomatic at entry and one third (717) had developed new-onset dyspepsia at the10-year follow up, giving an incidence of 2.8%. After multivariate logistic regression, lower quality of life at study entry, higher body mass index, presence of irritable bowel syndrome at study entry and use of non-steroidal anti-inflammatory drugs and/or aspirin were significant risk factors for new-onset dyspepsia (see table). Low quality of life at baseline exerted a strong effect on the likelihood of developing dyspepsia at 10 years. This has implications for treatment trials of
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