EDITOR'S QUIZ: GI SNAPSHOT
Familial liver disease
East Lancashire Hospitals NHS Trust, Blackburn, Lancashire, UK
Correspondence to:
Correspondence to:
Dr P D Mullins
Acute Unit, Burnley General Hospital, East Lancashire Hospitals NHS Trust, Casterton Avenue, Burnley, BB10 2PQ, UK; pauld.mullins@virgin.net
| The first 150 words of the full text of this article appear below. |
A 52-year-old man presented with malaise and abnormal liver function tests: alanine aminotransferase 71 IU/ml (0–50), 
-glutamyltransferase 465 IU/ml (0–60), alkaline phosphatase 167 IU/ml (30–140), bilirubin 19 µmol (3–28). He had never consumed alcohol, was on no regular drug treatment and had no medical history of note. His 53-year-old brother had died of renal disease and his sister had presented with fatal portal hypertensive haemorrhage at the age of 41 years. Clinical examination was unremarkable, full blood count Hb 12.5 g/dl (13.5–17.5), white blood count 2.5x109 (4–11), platelets 81x109/l (150–400), albumin, coagulation profile and immunoglobulins were normal. Viral markers for hepatitis and autoimmune serology were negative, abdominal ultrasound examination showed coarse architecture of the liver with normal-sized spleen. Oesophagogastroduodenoscopy showed grade IV oesophageal varices, a liver biopsy was carried out (figs 1
and 2).
Figure 1 Liver biopsy, H&E stain, low-power microscopy.
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Figure 2 Liver biopsy, H&E stain, | |||||||||
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EDITOR’S QUIZ: GI SNAPSHOT
Gut 2007 56: 732.[Extract] [Full Text] [PDF]
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