LETTER
Is gliadin really safe for non-coeliac individuals? Production of interleukin 15 in biopsy culture from non-coeliac individuals challenged with gliadin peptides
1 Department of Paediatrics & Immunology, Mucosal Immunology Laboratory, IBGM-University of Valladolid, Valladolid, Spain
2 Research Unit, Hospital Clínico Universitario, Valladolid, Spain
3 Depatment of Gastroenterology, Hospital Clínico Universitario, Valladolid, Spain
4 Digestive Service, Hospital Universitario Central de Asturias, Oviedo, Spain
5 Department of Paediatrics & Immunology, Mucosal Immunology Laboratory, IBGM-University of Valladolid, Valladolid, Spain
Correspondence to:
Correspondence to:
Dr E Arranz
Department of Paediatrics & Immunology, Mucosal Immunology Laboratory, IBGM-University of Valladolid, Spain. c/Ramón y Cajal, 7 47005, Valladolid, Spain; earranz@med.uva.es
| The first 150 words of the full text of this article appear below. |
Nowadays it is assumed that an innate immunity to gluten plays a key role in the development of coeliac disease (CD).1 This innate response, mediated by interleukin (IL) 15 and elicited by "toxic peptides", like the 19-mer, through a DQ2-independent mechanism, induces epithelial stress and reprogrammes intraepithelial lymphocytes into natural killer (NK)-like cells2 leading to enterocyte apoptosis and an increase in epithelium permeability. Thus, immunodominant peptides, like the 33-mer, can reach the lamina propria to trigger adaptive immunity. However, although an innate specific response in CD has been reported,3 no differential factors between patients with and without CD have been described controlling the innate immune response. Thus, since the toxic 19-mer elicits its harmful effect through a DQ2-independent mechanism, we hypothesise that the innate response is common in patients with and without CD, whereas the adaptive response is exclusive of susceptible patients with CD.
To test the hypothesis, biopsy cultures
This article has been cited by other articles:
-
Moron, B., Cebolla, A., Manyani, H., Alvarez-Maqueda, M., Megias, M., Thomas, M. d. C., Lopez, M. C., Sousa, C.
(2008). Sensitive detection of cereal fractions that are toxic to celiac disease patients by using monoclonal antibodies to a main immunogenic wheat peptide. Am. J. Clin. Nutr.
87: 405-414
[Abstract] [Full Text]
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
