COMMENTARY
Helicobacter bilis
Helicobacter bilis: bacterial provocateur orchestrates host immune responses to commensal flora in a model of inflammatory bowel disease
Correspondence to:
Correspondence to:
Dr J G Fox
Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Building 16, Room 825C, Cambridge, MA 02139, USA; jgfox@mit.edu
Helicobacter bilis can elicit heterologous immune responses to lower gut flora
| The first 150 words of the full text of this article appear below. |
The gastrointestinal tracts of mammals, including mice, are colonised with a diverse microecosystem. The caeca of normal conventional mice have been estimated to contain from 100 to 1000 individual species, and the number of bacteria can reach levels of up to 1011 bacteria/g of faeces.1,2 These microorganisms provide essential nutrients for their host and also colonise mucosal niches, which may partly influence the host response against microbial pathogens.2–7 By far, the greatest concentration and different types of bacteria comprising the gastrointestinal microflora of mice and humans reside in the caecum and colon.8,9,10 The fusiform-shaped bacteria, spirochetes and spiral-shaped bacteria were shown by histology to be almost exclusively located in the mucinous secretion overlaying the epithelium of the large bowel, and apparently in intimate association with the epithelial barrier.10 In the 1960s, Schaedler et al11 colonised germ-free mice with selected bacteria isolated from "normal" mice. He then supplied animal
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
Relevant Article
- Helicobacter bilis triggers persistent immune reactivity to antigens derived from the commensal bacteria in gnotobiotic C3H/HeN mice
- Albert E Jergens, Jennifer H Wilson-Welder, Andrea Dorn, Abigail Henderson, Zhiping Liu, Richard B Evans, Jesse Hostetter, and Michael J Wannemuehler
Gut 2007 56: 934-940.[Abstract] [Full Text] [PDF]
- Full Text
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- Citation Map
Services
- Email this link to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
