COMMENTARY
Role of COX2 in hepatitis
Complex roles of cyclo-oxygenase 2 in hepatitis
Liver Research Group, MRC Centre for Immune Regulation, The University of Birmingham Medical School, Birmingham, UK
Correspondence to:
Correspondence to:
Professor D Adams
Liver Research Group, 5th Floor IBR, The University of Birmingham Medical School, Wolfson Drive, Edgbaston, Birmingham B152TT, UK;d.h.adams@bham.ac.uk
There is currently insufficient evidence to support the use of COX-2 inhibitors in treating chronic hepatitis or in preventing liver fibrosis
| The first 150 words of the full text of this article appear below. |
There is a bark of an English tree, which I have found to be a powerful astringent, very efficacious in curing agues and intermitting disorders.1
So wrote the Reverend Edmund Stone in 1763 in a letter to the Royal Society wherein he described his success in treating patients with fever with an extract of powdered willow bark. Although willow extract was used in many ancient cultures as an antipyretic, the active component, salicylic acid, was not identified until the 19th century. The discovery of the chemical structure of salicylate by Herman Kolbe paved the way for the synthesis of acetylsalicylic acid by Bayer in the late 19th century. The mechanism by which it exerted its anti-inflammatory effects remained a mystery until John Vane revealed in the 1970s that aspirin and the newly developed non-steroidal anti-inflammatory drugs (NSAIDs) are non-selective inhibitors of cyclo-oxygenase (COX), the enzyme
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