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The suppressors of cytokine signalling (SOCS) have tumour suppressor activity (SOCS-1) and have been implicated in cancers of the liver and pancreas (SOCS-3). Tischoff et al studied the role of SOCS-1 and SOCS-3 in Barrett’s adenocarcinoma and its precursor lesions. Tumour DNA from Barrett’s adenocarcinomas, Barrett’s intraepithelial neoplasias (low and high grade), Barrett’s mucosa without neoplasia, normal squamous and gastric epithelium, and four cell lines were studied using methylation specific PCR following microdissection. Normal oesophageal squamous and gastric mucosa showed no SOCS-3 or SOCS-1 methylation. There was an increasing level of methylation of SOCS-3 in Barrett’s mucosa without intraepithelial neoplasia (13%), low grade (22%) and high grade intraepithelial neoplasias (69%), and Barrett’s adenocarcinomas (74%) (see table). Similar but smaller changes were seen for SOCS-1. Methylation of the SOCS-3 promoter correlated with downregulation of SOCS-3 transcripts and protein expression in these tumours and various cell lines. The authors conclude that promoter
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