COMMENTARY
Lipids and HCV
Do high lipids help clearance of hepatitis C?
Correspondence to:
Correspondence to:
Dr S Ryder
Queens Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham NG7 2RD, UK; stephen.ryder@nuh.nhs.uk
High triglyceride levels may be a factor in the high rate of spontaneous clearance of HCV
| The first 150 words of the full text of this article appear below. |
A large volume of evidence suggests that lipids and lipid receptors are important in hepatitis C infection.
Hepatic steatosis is common, with at least 65% of liver biopsy specimens demonstrating steatosis. In genotype 3 infection, a specific mechanism of steatosis induction exists, via core antigen expression. The incidence of diabetes is higher in hepatitis C virus (HCV) infection and increases with increasing severity of liver disease. The mechanism of this is via insulin resistance, but it is uncertain whether hepatic steatosis is a result of the insulin resistance or plays a pivotal role in its induction.
HCV is associated with lipid in the serum and almost certainly uses lipid receptors to enter hepatocytes. The low-density fractions of serum contain HCV RNA particles and lipoviral particles (LVP) associated with triglyceride (TG)-rich lipoproteins. Such particles rich in TG have been shown to contain viral capsid and RNA.1 TG is
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