COMMENTARY

Anti-TNF therapy

The classics in perspective

Julián Panés¹, Subrata Ghosh²

¹ Department of Gastroenterology, Hospital Clínic Barcelona, CIBER-EHD, Barcelona, Spain
² Imperial College London, Hammersmith Hospital, Du Cane Road, London, UK

Correspondence to:
Correspondence to:
Subrata Ghosh
Professor of Gastroenterology, Imperial College London, Hammersmith Hospital, London W12 0NN, UK; s.ghosh@imperial.ac.uk

Abbreviations: ACCENT, A Crohn’s disease Clinical trial Evaluating infliximab in a New long-term Treatment regimen; CHARM, Crohn’s Trial of the Fully Human Antibody Adalimumab; CLASSIC, CLinical assessment of Adalimumab Safety and efficacy Studied as an Induction therapy in Crohn’s; GAIN, Gauging Adalimumab efficacy in Infliximab Nonresponders; GETAID, Groupe d’Etudes Therapeutiques des Affections Inflammatoires Digestives; PRECISE, PEGylated antibody fRagment Evaluation in. Crohn’s disease: Safety and Efficacy; SONIC, SONIC (Study Of biologic and Immunomodulator Naive patients in Crohn’s disease; TNF, tumour necrosis factor

Keywords: adalimumab; Anti-TNF therapy; Crohn’s disease; inflammatory bowel disease

The first 150 words of the full text of this article appear below.

With the development and introduction of anti-cytokine therapies as biological agents, our therapeutic approach to Crohn disease and inflammatory diseases in general has dramatically expanded within the past few years. Biological agents technically mean a molecule that is the product of a biological system and functionally that is an agent that targets a specific biological molecule. Gastroenterologists are facing a remarkable wave of new biological therapies for inflammatory bowel diseases (IBD), including anti-tumour necrosis factor (TNF) antibodies (infliximab, adalimumab, certolizumab pegol), an anti-CD3 antibody (visilizumab), an anti-integrin antibody (natalizumab), and an anti-IL-12p40 and anti-IL6 receptor antibody (tocilizumab). Several biological therapies have also proven to be ineffective in large clinical trials, despite good initial promise, such as antibodies against soluble TNF receptors (etanercept, onercept), interleukin-10 and granulocyte–macrophage colony-stimulating factor (sargramostim).

Infliximab, an intravenously administered chimeric monoclonal antibody to TNF, has been for some years the only biological molecule approved . . . [Full text of this article]

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