Gut 2007;56:1325
LETTER
Remission and relapse of Crohn’s disease following autologous haematopoietic stem cell transplantation for non-Hodgkin’s lymphoma
Department of Gastroenterology, King’s College Hospital, London SE5 9RS, UK; guy.chung-faye@kingsch.nhs.uk
Keywords: Crohn’s disease; non-Hodgkin’s lymphoma; stem cell transplantation
| The first 150 words of the full text of this article appear below. |
Autologous haematopoietic stem cell transplantation (HSCT) for Crohn’s disease has been described by Oyama and co-workers as producing remission in 11 of 12 patients with refractory Crohn’s disease after a median follow up of 18.5 months.1 They postulated that autologous HSCT was useful for refractory Crohn’s disease. We report the case of a 32 year old woman with biopsy proven Crohn’s disease diagnosed when she was 16 years old. Her mother also suffered from Crohn’s disease. She developed a KI1 positive anaplastic non-Hodgkin’s lymphoma (NHL) three years later, treated successfully with ablative CHOP chemotherapy and autologous HSCT, inducing remission for the past 12 years (and she remains in remission on no treatment). As a consequence of her autologous HSCT she also went into long term remission from her Crohn’s disease, but relapsed after eight years. She was a smoker, but was on no maintenance treatment for Crohn’s disease in this
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