Commentaries
Genetic adjuvant therapy for pancreatic cancer and other solid tumours
Correspondence to:
Dr Kenneth Christopher Bagley, Profectus BioSciences, Inc., 1450 South Rolling Road, Baltimore, MD 21227, USA; Bagley@profectusbiosciences.com
| The first 150 words of the full text of this article appear below. |
Cancer malignancies are responsible for approximately a quarter of all deaths in the developed world. Primary tumours can often be treated successfully with surgical resection, chemotherapy or radiation; however, these therapies are mostly ineffective against metastatic spreading. For this reason, the elimination or control of metastases is a primary goal for new cancer therapies. Immunotherapies harness the innate ability of the immune system to recognise and eliminate tumours. After decades of debate, it is now accepted that the immune system plays an important role in preventing tumours and can be stimulated to eradicate established tumours.
One of the first observations supporting the involvement of the immune system in the control of cancer is that immunocompromised individuals and animals have a higher rate of spontaneous tumours. More recently, it has been shown that immune cells collect at tumour sites and specifically respond to tumour-associated antigens (TAAs). Genetic instability and overexpression cause
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Gut 2008 57: 344-351.[Abstract] [Full Text] [PDF]
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