Editor's quiz: GI snapshot
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From question on page 10.1136/gut.2006.115014
A distal pancreatectomy was performed. Gross pathology revealed a yellowish, elastic, well-encapsulated tumour measuring 2x2x2 cm, within the pancreatic tail. Microscopically, the tumour showed monotonous tumour cells separated by fibrous stroma, which was arranged in a papillary, glandular, solid or cystic pattern (fig 1). Immunohistochemical staining by the avidin–biotin complex method revealed that the tumour cells were positive for polyclonal AFP antibody (fig 1, inset). Tumor cells per se contained periodic acid–Schiff diastase-resistant cytoplasmic granules and reacted positively after immunohistochemistry for 
1-trypsin, indicating an acinar cell carcinoma. Serum AFP declined after surgery and stayed within the normal range during 4 years of follow-up. Neither tumour recurrence nor metastasis was noted during this follow-up.
Figure 1 Pathology reveals an acinar cell carcinoma with positive polyclonal
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