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A strong association between reflux oesophagitis (RO) and bronchial asthma (BA) is widely appreciated. However, the mechanisms involved in this interaction are uncertain, partly due to the lack of suitable animal models. Sugawa and coauthors present a novel rat model to explore these interactions. RO and BA were induced in rats and these were divided into four groups: control, RO, BA and RO+BA. Inflammatory responses in the airways and in the oesophagus were determined. In bronchoalveolar lavage fluid increased number of cells, especially eosinophils, as well as higher levels of interleukin 13 were seen in the RO+BA group compared with the BA group and this enhanced airway inflammation was prevented by rabeprazole treatment (see fig). Moreover, eosinophilic infiltration in the oesophageal submucosa and levels of mRNA expression of several cytokines were enhanced in the RO+BA versus RO group. This novel rat model, demonstrating significant interactions between RO and BA, will
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