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Once daily dosing undoubtedly improves compliance, so this study, comparing once daily with twice daily dosing of mesalazine, is encouraging. Patients with mild to moderate acute ulcerative colitis achieving remission in a previous 8-week study of either 2.4 g once daily, 1.2 g twice daily or 4.8 g once daily were entered into the present open-labelled 12-month maintenance trial comparing 1.2 g twice daily with 2.4 g daily. Those failing to respond to the initial 8-week’s treatment were offered a further 8 weeks of 2.4 g twice daily and, if they then achieved remission, were also entered into the maintenance trial. Of 459 patients randomised, 213 required the additional 8 weeks at 4.8 g daily to achieve remission. Adverse events were equally distributed between the two groups. Only one serious adverse event was considered to be related to the study treatment. Remission rates at 12 months were similar for the
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