Commentaries
After budesonide, what next for collagenous colitis?
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA
Correspondence to:
Dr D S Pardi, 200 First St SW, Rochester, MN 55905, USA; pardi.darrell@mayo.edu
| The first 150 words of the full text of this article appear below. |
Collagenous colitis, and the related condition lymphocytic colitis, are relatively common causes of watery diarrhoea, particularly in the elderly. Epidemiological studies suggest that the incidence of these conditions is increasing significantly.1 Despite these facts, there have been relatively few randomised controlled trials assessing treatment options. Budesonide has been assessed in at least three randomised, controlled induction studies in collagenous colitis2 and one in lymphocytic colitis,3 and is superior to placebo for the short-term treatment of these conditions. Unfortunately, although budesonide appears to be very effective for induction, the relapse rate is high once this medication is discontinued.4
Therefore, it is appropriate for clinicians and patients to ask, after budesonide, what next for collagenous colitis? There have now been two studies assessing budesonide maintenance therapy in collagenous colitis in a randomised, placebo controlled fashion. The first, by Bonderup and colleagues, appears in this issue of Gut (see page 68).5
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Relevant Article
- Long-term budesonide treatment of collagenous colitis: a randomised, double-blind, placebo-controlled trial
- O K Bonderup, J B Hansen, P S Teglbjærg, L A Christensen, and J F Fallingborg
Gut 2009 58: 68-72.[Abstract] [Full Text] [PDF]
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