Commentaries
Corticosteroid treatment for autoimmune pancreatitis
Fiterman Center for Digestive Diseases, Mayo Clinic, Rochester, Minnesota, USA
Correspondence to:
Correspondence to Dr Suresh T Chari, 200 First ST SW, Rochester, MN 55905, USA; chari.suresh@mayo.edu
| The first 150 words of the full text of this article appear below. |
Autoimmune pancreatitis (AIP) is the only pancreatic disorder responsive to steroid treatment. AIP has recently been subclassified into type 1 and type 2 AIP.1 Type 1 AIP is the pancreatic manifestation of immunoglobulin G4 (IgG4)-associated systemic disease (ISD), a fibroinflammatory autoimmune disorder that involves multiple organ systems and is characteristically associated with elevation of serum levels of IgG4.2 Commonly used diagnostic criteria for AIP include the Asian Consensus diagnostic criteria3 and the Mayo Clinic HISORt criteria4 (histology, imaging, serology, other organ involvement and response to corticosteroid treatment). Treatment protocols for AIP are still evolving, but corticosteroids are generally considered to be very effective in the initial inflammatory phase of the disease. Several small case series have reported that corticosteroids are effective in inducing remission in AIP, but larger series and controlled trials are lacking.
In this issue of Gut (see page 1504), Kamisawa and colleagues5 report results from
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- Standard steroid treatment for autoimmune pancreatitis
- T Kamisawa, T Shimosegawa, K Okazaki, T Nishino, H Watanabe, A Kanno, F Okumura, T Nishikawa, K Kobayashi, T Ichiya, H Takatori, K Yamakita, K Kubota, H Hamano, K Okamura, K Hirano, T Ito, S B H Ko, and M Omata
Gut 2009 58: 1504-1507.[Abstract] [Full Text] [PDF]
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