Digest
Digest
| The first 150 words of the full text of this article appear below. |
Eosinophilic oesophagitis is an increasingly recognised cause of dysphagia, characterised by >15 eosinophils/high powered field, basal zone hyperplasia and elongation of vascular papillae. Eosinophils release inflammatory mediators, the most abundant of which is major basic protein (MBP). The extracellular calcium sensing receptor (CaSR) is a G-protein-coupled receptor. The present study using an oesophageal cell line (HET-1A) showed that CaSR responds to MBP-peptide. Furthermore, when HET-1A cells were incubated with MBP-peptide there was a marked increase in fibroblast growth factor 9 (FGF9). Transfecting the cells with short interfering siRNACaSR blocked the production of FGF9 showing this was a CaSR dependent process. The authors also showed that FGF9 stimulates cell proliferation and that paediatric patients with a eosinophilic oesophagitis had a substantial increase in FGF9 in homogenates of oesophageal mucosal biopsies (see fig). Finally, the FGF9 was shown by immunohistochemistry to be increased in eosinophilic oesophagitis. By defining the mechanism whereby eosinophils
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
Relevant Articles
- Impairment of the intestinal barrier is evident in untreated but absent in suppressively treated HIV-infected patients
- H-J Epple, T Schneider, H Troeger, D Kunkel, K Allers, V Moos, M Amasheh, C Loddenkemper, M Fromm, M Zeitz, and J-D Schulzke
Gut 2009 58: 220-227.[Abstract] [Full Text] [PDF]
- Once daily versus three times daily mesalazine granules in active ulcerative colitis: a double-blind, double-dummy, randomised, non-inferiority trial
- W Kruis, G Kiudelis, I Rácz, I A Gorelov, J Pokrotnieks, M Horynski, M Batovsky, J Kykal, S Boehm, R Greinwald, R Mueller on behalf of the International Salofalk OD Study Group
Gut 2009 58: 233-240.[Abstract] [Full Text] [PDF]
- Vascular endothelial growth factor and angiopoietin-2 play a major role in the pathogenesis of vascular leakage in cirrhotic rats
- P Melgar-Lesmes, S Tugues, J Ros, G Fernández-Varo, M Morales-Ruiz, J Rodés, and W Jiménez
Gut 2009 58: 285-292.[Abstract] [Full Text] [PDF]
- Comparison of CT colonography, colonoscopy, sigmoidoscopy and faecal occult blood tests for the detection of advanced adenoma in an average risk population
- A Graser, P Stieber, D Nagel, C Schäfer, D Horst, C R Becker, K Nikolaou, A Lottes, S Geisbüsch, H Kramer, A C Wagner, H Diepolder, J Schirra, H J Roth, D Seidel, B Göke, M F Reiser, and F T Kolligs
Gut 2009 58: 241-248.[Abstract] [Full Text] [PDF]
- FGF9-induced proliferative response to eosinophilic inflammation in oesophagitis
- D J Mulder, I Pacheco, D J Hurlbut, N Mak, G T Furuta, R J MacLeod, and C J Justinich
Gut 2009 58: 166-173.[Abstract] [Full Text] [PDF]
- The effect of metabolic risk factors on the natural course of gastro-oesophageal reflux disease
- Y-C Lee, A M-F Yen, J J Tai, S-H Chang, J-T Lin, H-M Chiu, H-P Wang, M-S Wu, and T H-H Chen
Gut 2009 58: 174-181.[Abstract] [Full Text] [PDF]
Services
- Email this link to a friend
- Similar articles in this journal
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
