Digest
Digest
| The first 150 words of the full text of this article appear below. |
Fibrosis in inflammatory bowel disease is believed to be due to an excess deposition of extracellular matrix (ECM) by myofibroblasts and an impairment of the matrix degrading metalloproteinases (MMPs). Transforming growth factor-β (TGFβ) stimulates ECM synthesis and the level of MMPs are reduced by tissue inhibitors of metalloproteinase (TIMPs). This study examined uninflamed mucosa from 25 patients with Crohn’s disease (CD) with strictures and compared this with tissue from 18 patients with CD without stricturing. TGFβ was over expressed in myofibroblasts from mucosa overlying strictures (see fig). Binding of TGF activates the Smad proteins, phosphorylating Smad 2 and 3 whose action on gene transcription is inhibited by Smad 6 and 7. The authors showed an increase in phosphorylated Smad 2 and 3 from mucosa above the stricture and a decrease in the inhibitory Smad 6 and 7. There was also a reduction in mucosal MMP-12 and an increase in the
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
Relevant Articles
- Serum proteomic profiling of obese patients: correlation with liver pathology and evolution after bariatric surgery
- V Trak-Smayra, D Dargere, R Noun, M Albuquerque, C Yaghi, M-H Gannagé-Yared, P Bedossa, and V Paradis
Gut 2009 58: 825-832.[Abstract] [Full Text] [PDF]
- Transforming growth factor β signalling and matrix metalloproteinases in the mucosa overlying Crohn’s disease strictures
- A Di Sabatino, C L Jackson, K M Pickard, M Buckley, L Rovedatti, N A B Leakey, L Picariello, P Cazzola, G Monteleone, F Tonelli, G R Corazza, T T MacDonald, and S L Pender
Gut 2009 58: 777-789.[Abstract] [Full Text] [PDF]
- Plasma proteasome level is a reliable early marker of malignant transformation of liver cirrhosis
- L Henry, T Lavabre-Bertrand, L Vercambre, J Ramos, S Carillo, I Guiraud, P Pouderoux, M Bismuth, J-C Valats, C Demattei, Y Duny, I Chaze, N Funakoshi, J P Bureau, J-P Daurès, and P Blanc
Gut 2009 58: 833-838.[Abstract] [Full Text] [PDF]
- Visceral fat accumulation is an independent risk factor for hepatocellular carcinoma recurrence after curative treatment in patients with suspected NASH
- T Ohki, R Tateishi, S Shiina, E Goto, T Sato, H Nakagawa, R Masuzaki, T Goto, K Hamamura, F Kanai, H Yoshida, T Kawabe, and M Omata
Gut 2009 58: 839-844.[Abstract] [Full Text] [PDF]
- Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis
- E A M Festen, P Goyette, R Scott, V Annese, A Zhernakova, J Lian, C Lefèbvre, S R Brant, J H Cho, M S Silverberg, K D Taylor, D J de Jong, P C Stokkers, D Mcgovern, O Palmieri, J-P Achkar, R J Xavier, M J Daly, R H Duerr, C Wijmenga, R K Weersma, and J D Rioux
Gut 2009 58: 799-804.[Abstract] [Full Text] [PDF]
- Impact of toll-like receptor 4 on the severity of acute pancreatitis and pancreatitis-associated lung injury in mice
- R Sharif, R Dawra, K Wasiluk, P Phillips, V Dudeja, E Kurt-Jones, R Finberg, and A Saluja
Gut 2009 58: 813-819.[Abstract] [Full Text] [PDF]
Services
- Email this link to a friend
- Similar articles in this journal
- Add article to my folders
- Download to citation manager
- Request Permissions
Google Scholar
PubMed
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
