Commentaries

GLP-1 analogues: a new therapeutic approach to prevent ductopenia in cholangiopathies?

Ulrich Beuers¹, Burkhard Göke²

¹ Department of Gastroenterology & Hepatology, Academic Medical Center, University of Amsterdam, The Netherlands
² Department of Medicine II, Klinikum Grosshadern, University of Munich, Germany

Correspondence to:
Professor Ulrich Beuers, Department of Gastroenterology & Hepatology, G4-213, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands; u.h.beuers@amc.uva.nl

The first 150 words of the full text of this article appear below.

Incretins have attracted the attention of the medical community for a century.¹ They are secreted from the gastrointestinal tract into the splanchnic circulation in response to nutrient ingestion and enhance glucose-stimulated insulin secretion.² Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are the two incretins identified in animals and man. They are thought to be responsible for about 50–70% of glucose-stimulated insulin secretion after a meal.² GLP-1 has attracted particular attention since its identification 20 years ago because of its potent insulinotropic activity, inhibition of glucagon secretion, retardation of gastric emptying and also an anorectic effect. GLP-1 is a post-translational proteolytic product of the proglucagon gene and is formed by enteroendocrine L cells mainly residing in the distal ileum and colon. The effects of GLP-1 on , β and cells of pancreas islets and on other target organs including the lung, heart, kidney, intestine and various regions of the central . . . [Full text of this article]

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