© 2004 by BMJ Publishing Group Ltd & British Society of Gastroenterology
LETTER
Crohn’s ileitis after liver transplantation from a living related donor with Crohn’s disease
Cedars-Sinai Medical Center, UCLA School of Medicine, Los Angeles, California, USA
Correspondence to:
Correspondence to:
Dr K A Papadakis
Cedars-Sinai Medical Center, UCLA School of Medicine, 8700 Beverly Blvd, D-4063 Los Angeles, California 90048, USA; Papadakisk@cshs.org
Keywords: Crohn’s disease; ileitis; liver transplantation; living related donor
| The first 150 words of the full text of this article appear below. |
We read with interest the case described by Sonwalkar et al of a patient who developed fulminant Crohn’s colitis after allogeneic stem cell transplantation (ASCT) (Gut 2003;52:1518–21). Although the donor had no known Crohn’s disease (CD) and did not carry the IBD3 or IBD5 haplotypes associated with CD, HLA class III mismatches at IBD3 and a CD associated polymorphism of the 5'UTR of NOD2/CARD15 were present in the donor and in the reconstituted immune cell population of the recipient post ASCT. The authors hypothesised that adoptive transfer of CD susceptibility may have occurred between ACST donor and recipient.
Herein, we report a case of a patient who developed CD after receiving a living related liver transplant from a donor with known CD. A 24 year old female received a liver transplant from a living related donor for decompensated cirrhosis secondary to vertically transmitted chronic hepatitis C
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