European evidence based consensus on the diagnosis and management of Crohn’s disease: current management

S P L Travis¹, E F Stange², M Lémann³, T Öresland⁴, Y Chowers⁵, A Forbes⁶, G D’Haens⁷, G Kitis⁸, A Cortot⁹, C Prantera¹⁰, P Marteau¹¹, J-F Colombel¹², P Gionchetti¹³, Y Bouhnik¹⁴, E Tiret¹⁵, J Kroesen¹⁶, M Starlinger¹⁷, N J Mortensen¹⁸ for the European Crohn’s and Colitis Organisation (ECCO)

¹ John Radcliffe Hospital, Oxford, UK
² Chefarzt, Abteilung für Innere Medizin 1 Schwerpunkte Gastroenterologie, Hepatologie und Endokrinologie, Robert Bosch Krankenhaus, Stuttgart, Germany
³ Service de Gastroentérologie, Hôpital Saint-Louis, Paris, France
⁴ Colorectal Unit, Department of Surgery, Sahlgrenska Universiteitssjukhuset/Östra, Gothenburg, Sweden
⁵ Chaim Sheba Medical Center, Tel Hashomer, Israel 52621
⁶ University College Hospital, London, UK
⁷ Imelda GI Clinical Research Centre, Imelda Hospital, Bonheiden, Belgium
⁸ Imelda GI Clinical Research Centre, Imelda Hospital, Bonheiden, Belgium
⁹ Department of Gastroenterology, University Hospital, Lille, France
¹⁰ Azienda Ospedaliera S. Camillo-Forlanini, Unita Operativa di Gastroenterologia, Rome, Italy
¹¹ Hospital Européen Department of Gastroenterology, Paris, France
¹² Hospital Huriez, Department of HepatoGastroenterology, CH et U, Lille, France
¹³ Universita di Bologna, Bologna, Italy
¹⁴ Hospital Lariboisière, Department of Gastroenterology, Paris, France
¹⁵ Inserm, Paris, France, and Universite Pierre et Marie Curie, Paris, France
¹⁶ Chirurgische Klinik I (Allgemein-, Gefäß- und Thoraxchirurgie), Universitätsklinikum Benjamin Franklin, Freie Universität Berlin, Berlin, Germany
¹⁷ Institute of Pathology, University of Graz, Austria
¹⁸ Department of Colorectal Surgery, John Radcliffe, Oxford, UK

Correspondence to:
Correspondence to:
Dr S P L Travis
John Radcliffe Hospital, Oxford OX3 9DU, UK; simon.travis{at}orh.nhs.uk; Professor E F Stange, Department of Internal Medicine 1, Robert Bosch Krankenhaus, PO Box 501120, Auerbachstr 110, 70341 Stuttgart, Germany; Eduard.Stange{at}rbk.de

This second section of the European Crohn’s and Colitis Organisation (ECCO) Consensus on the management of Crohn’s disease concerns treatment of active disease, maintenance of medically induced remission, and surgery. The first section on definitions and diagnosis includes the aims and methods of the consensus, as well as sections on diagnosis, pathology, and classification of Crohn’s disease. The third section on special situations in Crohn’s disease includes postoperative recurrence, fistulating disease, paediatrics, pregnancy, psychosomatics, extraintestinal manifestations, and alternative therapy for Crohn’s disease.

Abbreviations: 5-ASA, mesalazine; AZA, azathioprine; CD, Crohn’s disease; CDAI, Crohn’s disease activity index; CRP, C reactive protein; CsA, cyclosporin; ECCO, European Crohn’s and Colitis Organisation; ESR, erythrocyte sedimentation rate; IBD, inflammatory bowel disease; IFX, infliximab; MTX, methotrexate; 6-MP, 6-mercaptopurine; NNH, number needed to harm; NNT, number needed to treat; UC, ulcerative colitis

Keywords: Crohn’s disease; treatment; mesalazine; corticosteroids; azathioprine; infliximab; surgery

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Sokol, H, Polin, V, Lavergne-Slove, A, Panis, Y, Treton, X, Dray, X, Bouhnik, Y, Valleur, P, Marteau, P (2009). Plexitis as a predictive factor of early postoperative clinical recurrence in Crohn's disease. Gut 58: 1218-1225 [Abstract] [Full Text]  
• Lee, S. S., Kim, A. Y., Yang, S.-K., Chung, J.-W., Kim, S. Y., Park, S. H., Ha, H. K. (2009). Crohn Disease of the Small Bowel: Comparison of CT Enterography, MR Enterography, and Small-Bowel Follow-Through as Diagnostic Techniques. Radiology 251: 751-761 [Abstract] [Full Text]  
• Stange, E. F, Travis, S. P L (2008). The European consensus on ulcerative colitis: new horizons?. Gut 57: 1029-1031 [Full Text]  
• Fujita, N., Itoh, T., Omori, H., Fukuda, M., Noda, T., Yoshimori, T. (2008). The Atg16L Complex Specifies the Site of LC3 Lipidation for Membrane Biogenesis in Autophagy. Mol. Biol. Cell 19: 2092-2100 [Abstract] [Full Text]  
• Shin, S. J., Collins, M. T. (2008). Thiopurine Drugs Azathioprine and 6-Mercaptopurine Inhibit Mycobacterium paratuberculosis Growth In Vitro. Antimicrob. Agents Chemother. 52: 418-426 [Abstract] [Full Text]  
• Cassinotti, A, Annaloro, C, Ardizzone, S, Onida, F, Volpe, A D., Clerici, M, Usardi, P, Greco, S, Maconi, G, Porro, G B., Deliliers, G L. (2008). Autologous haematopoietic stem cell transplantation without CD34+ cell selection in refractory Crohn's disease. Gut 57: 211-217 [Abstract] [Full Text]  
• Salar, A., Bessa, X., Muniz, E., Monfort, D., Besses, C., Andreu, M. (2007). Infliximab and adalimumab-induced thrombocytopenia in a woman with colonic Crohn's disease. Gut 56: 1169-1170 [Full Text]