The influence of obesity on the risk of developing colon cancer

Eldo E Frezza ^1*, Mitchell S Wachtel ¹ and Maurizio Chiriva-Internati ¹

¹ Texas Tech University Health Sciences Center, United States

^* To whom correspondence should be addressed. E-mail: eldo.frezza{at}ttuhsc.edu.

Accepted 13 September 2005

Abstract

Bulleted Summary: * Insulin is the best established biochemical mediator between obesity and colon cancer. Hyperinsulinemia, such as occurs in type II diabetes, is important in the pathogenesis of colon cancer. * All adipose tissue is not equal. Visceral abdominal fat has been identified as the essential fat depot for pathogenetic theories that relate obesity and colon cancer. * The genders differ as regards the relationship of obesity and colon cancer. Obesity imposes a greater risk of colon cancer for men of all ages and for pre- menopausal women than it does for post-menopausal women. * Regular exercise reduces the risk of developing colon cancer and the risk of death from colon cancer should it develop. * A combination of waist circumference and body mass index measurements is recommended to assess the obesity-related risk of developing colon cancer. Radiographic assessments of visceral abdominal fat may eventually prove to be the best means of assessing a patient's obesity-related risk of developing colon cancer.

Keywords: colon cancer, insulin, leptin, obesity, visceral abdominal fat

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