Gut. Published Online First: 19 July 2006. doi:10.1136/gut.2005.085365
Leading Article (commissioned only) |
Impaired gastric accommodation and its role in dyspepsia
1 University Hospital Gasthuisberg, Belgium
* To whom correspondence should be addressed. E-mail: jan.tack{at}med.kuleuven.ac.be.
Accepted 12 July 2006
Abstract
The accommodation reflex is an important mechanism of normal gastric physiology. In functional dyspepsia, impairment of accommodation has been found in 40%, but it has been described in a number of other upper gastrointestinal disorders such as diabetic gastropathy and post-fundoplication syndrome. This review focuses on the pathways involved in the normal accommodation reflex, the relevance of impaired gastric accommodation as a cause of morbidity, and the methods to assess gastric accommodation in man. We outline the available medical and therapeutic strategies based on the actual knowledge of the physiology and pharmacology of the accommodation reflex, with a focus on the role of nitrergic neurons and serotonergic receptors.
Keywords: functional dyspepsia, gastric accommodation, nitric oxide, serotonin
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Vanden Berghe, P., Janssen, P., Kindt, S., Vos, R., Tack, J.
(2009). Contribution of different triggers to the gastric accommodation reflex in humans. Am. J. Physiol. Gastrointest. Liver Physiol.
297: G902-G906
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