• Clostridium difficile
• diarrhoea
• immunoglobulin

I enjoyed reading Kyne and Kelly's therapy update concerning treatments for recurrent Clostridium difficile diarrhoea (Gut 2001; 49:152–3). Recurrence after a single episode of diarrhoea can occur in up to 50% of cases¹ and following recurrent bouts further relapse is even more likely. The authors have demonstrated that a serum antibody response to C difficile toxin A during an initial attack is associated with protection against recurrence¹ and suggested that intravenous immunoglobulin may be useful in treating refractory recurrent disease. Here I report successful treatment of four adult patients with recurrent C difficile infection using intravenous immunoglobulin in order to increase the number of reported cases.