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Research Article
HLA and cell-mediated immunity in HBsAg negative chronic active hepatitis.
  1. A J Vogten,
  2. R G Shorter,
  3. G Opelz

    Abstract

    In 20 patients with severe HBsAg negative chronic active hepatitis a significant association has been found between the HLA determinants A1, B8, and Dw3 and cell-mediated immunity directed against human liver specific lipoprotein in vitro. This observation induces further speculation that genetic immunoregulatory action might be involved in the pathogenetic mechanisms of chronic active hepatitis in vivo.

    https://doi.org/10.1136/gut.20.6.523

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