Article Text


Pepsin secretion in man after Histalog stimulation
  1. Michael D. Turner,
  2. Paula J. Mayer,
  3. Leon L. Miller,
  4. Harry L. Segal


    Human gastric juice shows three separable pepsin fractions on chromatography on DEAE-cellulose. The response of these fractions to stimulation with β-aminoethylpyrazole hydrochloride (Histalog) was studied. After a single intramuscular injection of Histalog (1·7 mg/kg body weight) there was an increase in the output of all three chromatographically distinguishable pepsin fractions. Little change was observed in the relative proportions of these three fractions and there was no evidence of selective stimulation of any individual fraction.

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    • 1 Supported by grants CA-09546 from the National Cancer Institute and 5-TO1-AM 5177 from the National Institute of Arthritis and Metabolic Diseases, United States Public Health Service.

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