Human gastric juice shows three separable pepsin fractions on chromatography on DEAE-cellulose. The response of these fractions to stimulation with β-aminoethylpyrazole hydrochloride (Histalog) was studied. After a single intramuscular injection of Histalog (1·7 mg/kg body weight) there was an increase in the output of all three chromatographically distinguishable pepsin fractions. Little change was observed in the relative proportions of these three fractions and there was no evidence of selective stimulation of any individual fraction.
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