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The effect of prolonged pancreatic secretion on blood acid-base balance in the conscious dog
  1. A. N. Fawcett,
  2. C. A. Newman

    Abstract

    Prolonged near maximal pancreatic secretion in conscious dogs has been found to result in a metabolic acidosis. This is mild and is accompanied by respiratory and other forms of compensation. Measurements of blood bicarbonate or base-excess changes cannot be used to estimate pancreatic bicarbonate output. The acidosis caused by pancreatic secretion cannot explain the changes in bicarbonate concentration seen in pancreatic juice during prolonged secretion.

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