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Changes of the smooth endoplasmic reticulum induced by rifampicin in human and guinea-pig hepatocytes
  1. A. M. Jezequel,
  2. F. Orlandi,
  3. L. T. Tenconi


    Rifampicin induces a proliferation of the smooth endoplasmic reticulum in guinea-pig and human hepatocytes. This may support the hypothesis of enhancement of drug-metabolizing enzymes induced by the drug. However, the pattern of proliferation is not similar in man and in guinea-pig hepatocytes. Some caution is needed in the study of enzyme induction in man and in extrapolations from animal to human data.

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    • 1 Part of this work was supported by research contract no. 70.-01927-04 from the CNR, Rome.

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