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The effect of lymphocytes from sufferers from recurrent aphthous ulceration upon colon cells in tissue culture
  1. A. E. Dolby

    Abstract

    The release of 51Cr from labelled colon cells was used to assess a possible lymphocytotoxic effect of peripheral blood lymphocytes from patients suffering from recurrent aphthous ulceration. No significant (p > 0·03) difference was observed between the isotope release following incubation with patients' or control lymphocytes. The absence of such a lymphocytotoxic effect, detectable with oral epithelial cells, is discussed in relation to the role of cellular hypersensitivity in the pathogenesis of ulcerative colitis and aphthous ulceration.

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