Article Text

PDF

Sieving characteristics of inflamed rectal mucosa
  1. J. Rask-Madsen

    Abstract

    The sieving characteristics of the normal and inflamed rectal mucosa are studied in three healthy volunteers and five patients with ulcerative colitis. Following rectal instillation of 125I-polyvinylpyrrolidone (PVP), the molecular size distribution of labelled PVP in urine samples was determined by Sephadex gel filtration. The results of the study suggest that the increased permeability of the inflamed rectal mucosa to electrolytes and small hydrophilic compounds is due primarily to ultrastructural changes since only the low molecular fractions of PVP were found in the urine.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.