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The effect of glucagon on serum gastrin
  1. M. G. Korman,
  2. C. Soveny,
  3. J. Hansky

    Abstract

    Serum gastrin was measured by radioimmunoassay in four patients with pernicious anaemia and four patients with the Zollinger-Ellison syndrome before and after the intravenous injection of 1 mg glucagon. Serum gastrin fell significantly in the patients with pernicious anaemia whilst in the patients with the Zollinger-Ellison syndrome there was a significant rise. Concomitant measurement of gastric acid output in one subject with the Zollinger-Ellison syndrome also showed a rise in acid output with glucagon.

    The reason for the paradoxical rise in gastrin in response to glucagon in the Zollinger-Ellison syndrome is unknown, but the response may provide a further diagnostic aid to this condition.

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    II Studies in pernicious anaemia and the Zollinger-Ellison syndrome

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