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The effect of intravenous infusions of prostaglandins E-2 and F-2alpha on human gastric function.
  1. A Newman,
  2. J P de Moraes-Filho,
  3. D Philippakos,
  4. J J Misiewicz

    Abstract

    The effect of intravenous infusions of prostaglandins E-2 and F(-2alpha) at various dose levels on basal, or on maximally or submaximally pentagastrin-stimulated acid secretion, was studied in 40 male subjects. Intraluminal antral pressures were also measured. Prostaglandin F (0.08 mug kg-minus 1 min-minus 1) transiently, but significantly, inhibited submaximal acid output and increased the frequency of antral contractions. Prostaglandin E(2)(0.08 mug kg-minus 1 min-minus 1) inhibited basal acid secretion.

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