Article Text


Continuous monitoring of the effect of pentagastrin on gastric emptying of solid food in man.
  1. S G Hamilton,
  2. H J Sheiner,
  3. M F Quinlan


    By continuous monitoring of a solid meal labelled with a radiopharmaceutical it has been possible to determine the effects of drugs on gastric emptying and motility during a single study. Predictably hyoscine delayed, and bethanechol increased, the rate of gastric emptying. Pentagastrin initially produced marked antral activity resulting in a physiological stricture and subsequent delay in the overall rate of gastric emptying. Fundal motility was unaffected though reflux from the antrum occurred.

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