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Successful treatment of a malignant gastrinoma with streptozotocin.
  1. J R Hayes,
  2. N O'Connell,
  3. T O'Neill,
  4. J J Fennelly,
  5. D G Weir

    Abstract

    The treatment with streptozotocin of a patient with metastatic gastrinoma is described. Two courses of intravenous streptozotocin were without effect. However, three months after two doses of 4 g streptozotocin were given into the coeliac axis, there was a marked reduction in hepatic size and a fall in fasting plasma gastrin levels from 1430 pmol/l to 240 pmol/l. Seven months after treatment fasting plasma gastrin levels were 125 pmol/l.

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