Article Text


Reduction in peripheral blood K cells and activated T cells in primary biliary cirrhosis.
  1. G P Sandilands,
  2. R N Macsween,
  3. K G Gray,
  4. R J Holden,
  5. P Mills,
  6. F M Reid,
  7. M A Thomas,
  8. G Watkinson


    Lymphocyte subpopulations were measured in the peripheral blood of 13 patients with primary biliary cirrhosis (PBC), 13 with chronic active hepatitis (CAH), and 16 age- and sex-matched normal subjects. A significant, relative and absolute, reduction in activated T cells and K cells, compared with that in normal subjects, was found in PBC but not in CAH. The reduction in K cells observed in PBC was found to be accompanied by a parallel decrease in lymphocyte-mediated antibody-dependent cytotoxicity.

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