Article Text


The histamine test meal in the rat
  1. L. S. Valberg,
  2. L. J. Witts


    A histamine test meal is described for the estimation of the secretion of gastric acid and pepsin in the unanaesthetized intact rat.

    The stomach of the rat secreted pepsin and a small amount of acid in response to the test meal of hypertonic sucrose. Stimulation with histamine produced a pronounced rise in acid secretion but the output of pepsin remained unchanged. The increase in acid secretion was correlated in the individual rat with a rise in the volume of gastric secretion. Histamine phosphate in a dose of 50 mg./kg. body weight produced maximal stimulation of gastric acid secretion and was free from toxic effects. Choline chloride, in a dose of 126·5 mg./kg. body weight, had no effect on the volume of gastric secretion and it was ineffective as a stimulant of either acid or pepsin secretion.

    Statistics from

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.