Studies of gastric acid secretion and mucosal appearances have been made in a group of 14 patients suffering from hypopituitarism. Achlorhydria was found in six of the patients suffering from Addison's disease but in only one patient suffering from hypopituitarism. In both groups the mean gastric secretion of hydrochloric acid was considerably lower than in a group of control subjects and replacement therapy with cortisone and DOCA in Addison's disease and cortisone and thyroid extract in hypopituitarism failed to restore gastric function to normal. A constant correlation was not found between gastric acid secretion and mucosal appearances.
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