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Gut 1979;20:55-58 doi:10.1136/gut.20.1.55
  • Research Article

Jejunal lysozyme activity and the Paneth cell in coeliac disease.

  1. M Ward,
  2. A Ferguson,
  3. M A Eastwood

      Abstract

      The jejunal mucosa of patients with coeliac disease contains significantly fewer Paneth cells (PCC) per crypt (p less than 0.001) and tissue lysozyme activity (JLA) P less than 0.001) when compared with a group of subjects with normal jejunal mucosa. Neither PCC nor JLA return to normal with complete clinical recovery and otherwise complete histological recovery on a gluten free diet. There is a significant linear correlation between JLA and PCC suggesting that the Paneth cell is the principal source of jejunal lysozyme.

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