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Effects of [Asu1,7]-eel calcitonin on gastric somatostatin and gastrin release.
  1. T Chiba,
  2. T Taminato,
  3. S Kadowaki,
  4. Y Goto,
  5. K Mori,
  6. Y Seino,
  7. H Abe,
  8. K Chihara,
  9. S Matsukura,
  10. T Fujita,
  11. T Kondo

    Abstract

    Effects of [Asu1,7]-eel calcitonin on gastric somatostatin and gastrin secretion were studied by using the isolated perfused rat stomach. [Asu1,7]-eel calcitonin (10(-9)--10(-7)M) caused a simultaneous dose-dependent increase of gastric somatostatin release and decrease of gastrin secretion, with a significant correlation between these two. The demonstration of calcitonin stimulation of gastric somatostatin release raises the possibility of somatostatin-mediated suppression of gastrin secretion by calcitonin.

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