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Effect of treatment on Campylobacter pylori in peptic disease: a randomised prospective trial.
  1. H Humphreys,
  2. S Bourke,
  3. C Dooley,
  4. D McKenna,
  5. B Power,
  6. C T Keane,
  7. E C Sweeney,
  8. C O'Moráin
  1. Department of Clinical Microbiology, St James's Hospital, Dublin, Ireland.

    Abstract

    This study investigated the effect of colloidal bismuth subcitrate and cimetidine on Campylobacter pylori in peptic disease. In 74% of 135 patients with peptic disease diagnosed at endoscopy C pylori was detected before treatment. Compared with cimetidine, colloidal bismuth subcitrate significantly decreased the incidence of C pylori after six weeks of treatment (p less than 0.001). In the colloidal bismuth subcitrate group, subsequent healing of the lesion was correlated with the clearance of C pylori, unlike in the cimetidine group. C pylori was strongly associated with the presence of histological gastritis, which was decreased by colloidal bismuth subcitrate (p less than 0.001).

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