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Is a persistent adenovirus infection involved in coeliac disease?
  1. M J Carter,
  2. M M Willcocks,
  3. H C Mitchison,
  4. C O Record,
  5. C R Madeley
  1. Department of Virology, University of Newcastle-upon-Tyne.

    Abstract

    Recent evidence has implicated adenovirus 12 in the aetiology of coeliac disease so that persistent infection by this virus must be considered. We have undertaken a search for adenovirus DNA in duodenal biopsy samples from a total of 26 coeliac and non-coeliac patients. We could find no evidence of persistent virus DNA by Southern blot techniques even under conditions which approach a sensitivity of one copy of virus genome per cell, and use either adenovirus 12 or 41 DNA.

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