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Defective suppression in the autologous mixed lymphocyte reaction in patients with Crohn's disease.
  1. D Kelleher,
  2. A Murphy,
  3. C A Whelan,
  4. C Feighery,
  5. D G Weir,
  6. P W Keeling
  1. Department of Clinical Medicine, Trinity College Dublin, Medical School, St James' Hospital, Dublin.

    Abstract

    T helper and suppressor cell control of autologous immunoglobulin production was measured in 14 patients with Crohn's disease (CD) using autologous B cells or monocytes to stimulate regulatory T-cell activity. A pronounced defect in suppressor cell function was observed in the patient group but not in matched controls irrespective of whether B cells or monocytes were used as the stimulus. This defect was observed for IgG, A and M. This defect was seen both in patients with active disease and with inactive CD suggesting the possibility that a primary regulatory defect might exist in this disease. The patient group displayed normal helper cell function.

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