Disposition of 5-aminosalicylic acid by olsalazine and three mesalazine preparations in patients with ulcerative colitis: comparison of intraluminal colonic concentrations, serum values, and urinary excretion.

L Staerk Laursen; M Stokholm; K Bukhave; J Rask-Madsen; K Lauritsen

doi:10.1136/gut.31.11.1271

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Research Article

Disposition of 5-aminosalicylic acid by olsalazine and three mesalazine preparations in patients with ulcerative colitis: comparison of intraluminal colonic concentrations, serum values, and urinary excretion.

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	Abstract	Full	Pdf
Jan 1999	8	0	0
Mar 1999	1	0	0
Apr 1999	1	0	0
Jul 1999	1	0	0
Sep 1999	1	0	0
Oct 1999	3	0	0
Nov 1999	1	0	0
May 2000	2	0	0
Aug 2000	1	0	0
Oct 2000	1	0	0
Nov 2000	1	0	0
Dec 2000	1	0	0
Apr 2001	1	0	0
May 2001	1	0	0
Jun 2001	2	0	0
Nov 2001	4	0	0
Jan 2002	1	0	0
Apr 2002	1	0	0
Jul 2002	1	0	0
Sep 2002	2	0	0
Oct 2002	1	0	0
Nov 2002	4	0	0
Dec 2002	1	0	0
Feb 2003	4	0	0
Mar 2003	3	0	0
May 2003	1	0	0
Jul 2003	4	0	0
Aug 2003	9	0	0
Sep 2003	8	0	0
Oct 2003	9	0	0
Nov 2003	12	0	0
Dec 2003	8	0	0
Jan 2004	10	0	0
Feb 2004	6	0	0
Mar 2004	12	0	0
Apr 2004	6	0	0
May 2004	12	0	0
Jun 2004	19	0	0
Jul 2004	11	0	0
Aug 2004	11	0	0
Sep 2004	3	0	0
Oct 2004	7	0	0
Nov 2004	5	0	0
Dec 2004	8	0	0
Jan 2005	13	0	0
Feb 2005	4	0	0
Mar 2005	11	0	0
Apr 2005	3	0	0
May 2005	6	0	0
Jun 2005	9	0	0
Jul 2005	8	0	0
Aug 2005	5	0	0
Sep 2005	6	0	0
Oct 2005	7	0	0
Nov 2005	9	0	0
Dec 2005	7	0	0
Jan 2006	5	0	0
Feb 2006	10	0	0
Mar 2006	12	0	0
Apr 2006	7	0	0
May 2006	3	0	0
Jun 2006	1	0	0
Jul 2006	4	0	0
Aug 2006	8	0	0
Sep 2006	5	0	0
Oct 2006	1	0	0
Nov 2006	9	0	0
Dec 2006	7	0	0
Jan 2007	5	0	0
Feb 2007	1	0	0
Mar 2007	9	0	0
Apr 2007	1	0	0
May 2007	8	0	0
Jun 2007	5	0	0
Jul 2007	3	0	0
Sep 2007	1	0	0
Oct 2007	5	0	9
Nov 2007	0	0	2
Dec 2007	2	0	1
Jan 2008	2	0	0
Feb 2008	1	0	5
Mar 2008	3	0	1
Apr 2008	3	0	10
May 2008	6	0	5
Jun 2008	4	0	2
Jul 2008	3	0	6
Aug 2008	4	0	3
Sep 2008	9	0	7
Oct 2008	10	0	4
Nov 2008	3	0	3
Dec 2008	13	0	14
Jan 2009	5	0	5
Feb 2009	6	0	21
Mar 2009	6	0	2
Apr 2009	10	0	1
May 2009	5	0	1
Jun 2009	7	0	1
Jul 2009	10	0	7
Aug 2009	8	0	6
Sep 2009	8	0	3
Oct 2009	9	0	4
Nov 2009	6	0	5
Dec 2009	2	0	2
Jan 2010	13	0	6
Feb 2010	14	0	6
Mar 2010	5	0	3
Apr 2010	10	0	1
May 2010	3	0	2
Jun 2010	10	0	5
Jul 2010	4	0	4
Aug 2010	8	0	0
Sep 2010	9	0	3
Oct 2010	6	0	5
Nov 2010	4	0	3
Dec 2010	5	0	4
Jan 2011	5	0	1
Feb 2011	13	0	4
Mar 2011	12	0	6
Apr 2011	9	0	5
May 2011	11	0	2
Jun 2011	7	0	4
Jul 2011	15	0	8
Aug 2011	5	0	3
Sep 2011	9	0	1
Oct 2011	6	0	4
Nov 2011	11	0	3
Dec 2011	8	0	8
Jan 2012	9	0	4
Feb 2012	3	0	4
Mar 2012	14	0	11
Apr 2012	3	0	7
May 2012	6	0	18
Jun 2012	7	0	7
Jul 2012	10	0	14
Aug 2012	11	0	12
Sep 2012	5	1	12
Oct 2012	11	0	15
Nov 2012	20	0	14
Dec 2012	11	0	12
Jan 2013	10	0	12
Feb 2013	16	0	14
Mar 2013	15	0	23
Apr 2013	15	1	22
May 2013	12	0	9
Jun 2013	19	0	22
Jul 2013	15	0	14
Aug 2013	9	0	29
Sep 2013	12	0	21
Oct 2013	10	0	5
Nov 2013	10	0	13
Dec 2013	10	0	14
Jan 2014	12	0	18
Feb 2014	9	0	23
Mar 2014	9	0	16
Apr 2014	13	0	23
May 2014	9	0	16
Jun 2014	5	0	9
Jul 2014	27	0	9
Aug 2014	12	0	22
Sep 2014	13	0	83
Oct 2014	20	0	146
Nov 2014	4	0	16
Dec 2014	4	0	4
Jan 2015	6	0	6
Feb 2015	6	0	10
Mar 2015	7	0	6
Apr 2015	3	0	1
May 2015	10	1	4
Jun 2015	9	0	5
Jul 2015	8	0	3
Aug 2015	5	0	1
Sep 2015	15	0	9
Oct 2015	7	0	6
Nov 2015	10	0	8
Dec 2015	3	0	3
Jan 2016	10	0	7
Feb 2016	5	0	11
Mar 2016	13	0	17
Apr 2016	6	0	14
May 2016	12	0	11
Jun 2016	7	0	9
Jul 2016	5	0	14
Aug 2016	12	1	9
Sep 2016	5	0	46
Oct 2016	3	0	12
Nov 2016	6	0	7
Dec 2016	15	0	10
Jan 2017	16	0	5
Feb 2017	10	1	10
Mar 2017	13	0	5
Apr 2017	18	0	11
May 2017	5	0	5
Jun 2017	7	0	11
Jul 2017	18	0	6
Aug 2017	22	0	5
Sep 2017	26	0	11
Oct 2017	36	0	2
Nov 2017	16	0	6
Dec 2017	20	0	5
Jan 2018	34	0	6
Feb 2018	18	0	5
Mar 2018	22	0	9
Apr 2018	34	0	13
May 2018	12	0	15
Jun 2018	18	0	8
Jul 2018	16	0	5
Aug 2018	22	0	15
Sep 2018	20	0	9
Oct 2018	36	0	11
Nov 2018	46	0	12
Dec 2018	22	0	2
Jan 2019	8	0	3
Feb 2019	14	0	10
Mar 2019	12	0	6
Apr 2019	16	0	10
May 2019	12	0	10
Jun 2019	12	0	13
Jul 2019	28	0	14
Aug 2019	14	0	9
Sep 2019	12	0	10
Oct 2019	18	0	12
Nov 2019	14	0	7
Dec 2019	14	0	11
Jan 2020	22	0	11
Feb 2020	8	0	9
Mar 2020	10	0	9
Apr 2020	18	0	5
May 2020	10	0	11
Jun 2020	14	0	10
Jul 2020	16	0	8
Aug 2020	18	0	6
Sep 2020	36	0	16
Oct 2020	14	0	12
Nov 2020	30	0	13
Dec 2020	28	0	14
Jan 2021	40	0	11
Feb 2021	12	0	16
Mar 2021	10	0	13
Apr 2021	2	0	1
May 2021	4	0	5
Jun 2021	0	0	4
Jul 2021	0	0	16
Aug 2021	0	0	5
Sep 2021	0	0	7
Oct 2021	14	0	21
Nov 2021	28	0	18
Dec 2021	38	0	10
Jan 2022	32	0	8
Feb 2022	7	0	3
Mar 2022	26	0	11
Apr 2022	21	0	12
May 2022	38	0	9
Jun 2022	46	0	7
Jul 2022	36	0	5
Aug 2022	48	0	6
Sep 2022	46	0	6
Oct 2022	42	0	8
Nov 2022	40	0	4
Dec 2022	38	0	4
Jan 2023	38	0	9
Feb 2023	68	0	5
Mar 2023	34	0	4
Apr 2023	34	0	7
May 2023	24	0	8
Jun 2023	22	0	2
Jul 2023	24	0	7
Aug 2023	20	0	6
Sep 2023	28	0	8
Oct 2023	26	0	3
Nov 2023	56	0	10
Dec 2023	56	0	2
Jan 2024	42	0	0
Feb 2024	52	0	2
Mar 2024	76	0	2
Total	3415	5	1879

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